Article
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets.
Hepatology (Baltimore, Md.) - 1 Jan 2007
Boyault Sandrine, Rickman David S, de Reyniès Aurélien, Balabaud Charles, Rebouissou Sandra, Jeannot Emmanuelle, Hérault Aurélie, Saric Jean, Belghiti Jacques, Franco Dominique, Bioulac-Sage Paulette, Laurent-Puig Pierre, Zucman-Rossi Jessica
Abstract excerpt
UNLABELLED: Hepatocellular carcinomas (HCCs) are a heterogeneous group of tumors that differ in risk factors and genetic alterations. We further investigated transcriptome-genotype-phenotype correlations in HCC. Global transcriptome analyses were performed on 57 HCCs and 3 hepatocellular adenomas and validated by quantitative RT-PCR using 63 additional HCCs. We determined loss of heterozygosity, gene mutations,...
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