Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caffeic acid phenethyl ester attenuates phenotypic switching and inflammation in abdominal aortic aneurysm via the NF-κB pathway.

Molecular biology reports - 11 May 2026

Gu Yuanyuan, Cao Chunshui, Liu Jian, Liu Yong, Huang Liang, Zhan Zuan

Abstract excerpt

BACKGROUND: In our previous animal experiments, we found that caffeic acid phenethyl ester (CAPE) inhibited the early formation of elastase-induced abdominal aortic aneurysms (AAA) in rats. However, its efficacy in the angiotensin II (Ang II)-induced AAA model and the underlying mechanism remain unclear. Therefore, the primary aim of this study was to further validate the potential mechanism of CAPE through in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Angiotensin II
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Inflammation

Share to Myocytes, Smooth Muscle

Share to NF-kappa B

Share to Osteopontin

Source

Identifiers

PMID: 42113350
DOI: 10.1007/s11033-026-11924-6

Genes

BAX
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caffeic acid phenethyl ester attenuates phenotypic switching and inflammation in abdominal aortic aneurysm via the NF-κB pathway.PMID 42113350Read ↗

Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice.Semantic proximity Read ↗

Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle CellsSemantic proximity Read ↗

Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.Semantic proximity Read ↗

Berberine Inhibits Abdominal Aortic Aneurysm Formation and Vascular Smooth Muscle Cell Phenotypic Switching by Regulating the Nrf2 Pathway.Semantic proximity Read ↗

Effectiveness of cyclooxygenase-2 inhibition in limiting abdominal aortic aneurysm progression in mice correlates with a differentiated smooth muscle cell phenotype.Semantic proximity Read ↗

The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation.Semantic proximity Read ↗

Genetic Ablation of miR-146a Induces Abdominal Aortic Aneurysm Formation by Intensifying Inflammatory M1-Like Macrophages Polarization and Vascular Smooth Muscle Cell Phenotypic Switching.Semantic proximity Read ↗

Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High Mobility Group Box 1 Production and Inhibit Abdominal Aortic Aneurysms.Semantic proximity Read ↗

7-O-methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells.Semantic proximity Read ↗

Sulforaphane prevents abdominal aortic aneurysm formation through the inhibition of phenotypic switching of vascular smooth muscle cells and inflammation via the activation of Nrf2.Semantic proximity Read ↗

Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy.Semantic proximity Read ↗

Tirzepatide mitigates thoracic aortic aneurysm and dissection by alleviating the loss of the contractile phenotype in vascular smooth muscle cells and reducing vascular inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.