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Uncovering Coenzyme Q10-Related Genetic Determinants of Statin-Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program.

Clinical pharmacology and therapeutics - 1 Aug 2026

Lee Da Hoon, Park Yoon-A, Song Yubin, Han Ji-Min, Choi Kyung Hee, Kim Myeong Gyu, Gwak Hye Sun

Abstract excerpt

Statin-associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome-wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10 measurements are unavailable in large-scale proteomic...

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PMID: 42109163
DOI: 10.1002/cpt.70325
PMCID: PMC13339052

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COQ7

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