Article
Genetic determinants of statin intolerance.
Lipids in health and disease - 21 Mar 2007
Oh Jisun, Ban Matthew R, Miskie Brooke A, Pollex Rebecca L, Hegele Robert A
Abstract excerpt
BACKGROUND: Statin-related skeletal muscle disorders range from benign myalgias--such as non-specific muscle aches or joint pains without elevated serum creatinine kinase (CK) concentration--to true myositis with >10-fold elevation of serum CK, to rhabdomyolysis and myoglobinuria. The genetic basis of statin-related muscle disorders is largely unknown. Because mutations in the COQ2 gene are associated with severe...
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