Rare variants in known and novel candidate genes predisposing to statin-associated myopathy.

doi:10.2217/pgs-2016-0071

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Article

Rare variants in known and novel candidate genes predisposing to statin-associated myopathy.

Pharmacogenomics - 1 Aug 2016

Neřoldová Magdaléna, Stránecký Viktor, Hodaňová Kateřina, Hartmannová Hana, Piherová Lenka, Přistoupilová Anna, Mrázová Lenka, Vrablík Michal, Adámková Věra, Hubáček Jaroslav A, Jirsa Milan, Kmoch Stanislav

Abstract excerpt

AIM: Genetic variants affecting statin uptake, metabolism or predisposing to muscular diseases may confer susceptibility to statin-induced myopathy. Besides the SLCO1B1 rs4149056 genotype, common genetic variants do not seem to determine statin-associated myopathy. Here we aimed to address the potential role of rare variants. METHODS: We performed whole exome sequencing in 88 individuals suffering from...

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Identifiers

PMID: 27296017
DOI: 10.2217/pgs-2016-0071

Genes

CLCN1
FBXO32
MYOT
RBM20

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