RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms

Abstract excerpt

AIM: To examine the genetic differences between subjects with statin-associated muscle symptoms and statin-tolerant controls. MATERIALS & METHODS: Next-generation sequencing was used to characterize the exomes of 76 subjects with severe statin-associated muscle symptoms and 50 statin-tolerant controls. RESULTS: 12 probably pathogenic variants were found within the RYR1 and CACNA1S genes in 16% of cases with...

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