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Article

Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex.

RNA (New York, N.Y.) - 1 Jul 2009

Schwer Beate, Schneider Susanne, Pei Yi, Aronova Anna, Shuman Stewart

Abstract excerpt

The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. Here we characterize the Schizosaccharomyces pombe core Spt5-Spt4 complex as a heterodimer and map a trypsin-resistant Spt4-binding domain within the Spt5 subunit. A genetic analysis of Spt4 in S. pombe revealed it to be...

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Identifiers

PMID: 19460865
DOI: 10.1261/rna.1572709
PMCID: PMC2704081

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Source receipt: pubmed, retrieved 7 Sept 2026.

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