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Article

Comorbidity Alters the Genetic Relationship Between Anxiety Disorders and Major Depression.

Biological psychiatry - 15 Sept 2026

Tesfaye Markos, Shadrin Alexey, Parker Nadine, Jaholkowski Piotr, Parekh Pravesh, Kutrolli Gleda, Birkenæs Viktoria, Bakken Nora R, Ask Helga, Hindley Guy, Frei Oleksandr, Djurovic Srdjan, Dale Anders M, Smeland Olav B, O'Connell Kevin S, Andreassen Ole A

Abstract excerpt

BACKGROUND: The extensive genetic overlap between anxiety disorders (ANX) and major depression (MD) may partly reflect the inclusion of comorbid cases in genome-wide association studies (GWASs). We investigated this genetic relationship between ANX and MD, with and without mutual comorbidity. METHODS: Using the UK Biobank, we performed disorder-specific GWASs for ANX-only (cases/controls = 9980/179,442) and...

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PMID: 42107849
DOI: 10.1016/j.biopsych.2026.04.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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