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Article

Heritability and polygenic load for comorbid anxiety and depression.

Translational psychiatry - 27 Mar 2025

Tabrizi Fara, Rosén Jörgen, Grönvall Hampus, William-Olsson Victor Rahimzadeh, Arner Erik, Magnusson Patrik Ke, Palm Camilla, Larsson Henrik, Viktorin Alexander, Bernhardsson Jens, Björkdahl Johanna, Jansson Billy, Sundin Örjan, Zhou Xuan, Speed Doug, Åhs Fredrik

Abstract excerpt

Anxiety and depression commonly occur together resulting in worse health outcomes than when they occur in isolation. We aimed to determine whether the genetic liability for comorbid anxiety and depression was greater than when anxiety or depression occurred alone. Data from 12,792 genotyped twins (ages 38-85) were analysed, including 1,986 complete monozygotic and 1,594 complete dizygotic pairs. Outcomes were...

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PMID: 40140358
DOI: 10.1038/s41398-025-03325-3
PMCID: PMC11947153

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