Shared genetic architecture and pathways linking major depressive disorder and autoimmune thyroid disease: insights from common and rare variants.

doi:10.1038/s41398-026-04146-8

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Article

Shared genetic architecture and pathways linking major depressive disorder and autoimmune thyroid disease: insights from common and rare variants.

Translational psychiatry - 1 Jun 2026

Liu Siyi, Zeng Yu, Xiao Liling, Wu Yulu, Hou Can, Yang Huazhen, Wei Menghan, Tang Yiguo, Huang Yunqi, Liu Yunjia, Ma Qianshu, Yin Yubing, Zhang Mengting, Chen Yang, Song Huan, Wang Qiang

Abstract excerpt

Major depressive disorder (MDD) and autoimmune thyroid disease (AITD) frequently co-occur, yet the genetic factors underlying their comorbidity remain unclear. We performed a population-matched cohort study from the UK Biobank to evaluate the phenotypic association between MDD and AITD. Genetic correlation, causal relationships, and pleiotropic loci/genes shared between the diseases were assessed based on common...

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PMID: 42225622
DOI: 10.1038/s41398-026-04146-8
PMCID: PMC13438702

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