High frequency of the HLA-G*01:05N null allele in Beninese populations and its potential impact on reduced soluble HLA-G expression.

doi:10.1016/j.meegid.2026.105955

Article

High frequency of the HLA-G*01:05N null allele in Beninese populations and its potential impact on reduced soluble HLA-G expression.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2026

Biaou Djelili, Lecat Marianne, Silva Nayane S B, Ganesh Koushik, Manso Justine, Sadissou Ibrahim, Sabbagh Audrey, Milet Jacqueline, Dechavanne Célia, Massougbodji Achille, Donadi Eduardo A, Garcia André, Castelli Erick C, Courtin David, Gineau Laure

Abstract excerpt

Human Leucocyte Antigen (HLA)-G, a non-classical HLA class Ib molecule, is involved in feto-maternal immune tolerance. Among HLA-G alleles, HLA-G*01:05N is defined by a cytosine deletion (ΔC) at exon 3, which causes a premature stop codon at position 189 in exon 4, disrupting the translation of HLA-G1, HLA-G4, and HLA-G5 isoforms. The modulation of HLA-G expression in carriers of the HLA-G*01:05N allele could...

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High frequency of the HLA-G*01:05N null allele in Beninese populations and its potential impact on reduced soluble HLA-G expression.

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