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Article

Bidirectional causal associations between immune cell phenotypes and age-related macular degeneration subtypes: A mendelian randomization study.

Experimental gerontology - 1 Apr 2026

Zhuang Zihao, Jia Xinyu, Lin Haixia, Hu Pengcheng, Hu Jianmin

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, characterized by two primary subtypes: dry AMD (dAMD) and wet AMD (wAMD). While immune mechanisms are implicated in AMD pathogenesis, the causal relationships between specific immune cell phenotypes and AMD subtypes remain incompletely characterized. METHODS: Bidirectional two-sample...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41722793
DOI: 10.1016/j.exger.2026.113074

Genes

CD4
CD14
CD28

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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