Article

Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.

2022-11-30

Abstract excerpt

<title>Abstract</title> MHC-I-opathies are inflammatory conditions strongly associated with HLA class I genes. The striking association with HLA class I suggests involvement of T cells, whereas natural killer (NK) cell involvement remains largely unstudied. Here we show that HLA-A29-positive birdshot chorioretinopathy patients have a skewed NK cell pool containing expanded CD16-positive NK cells which produce...

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Literature Corpus work: 48161aaa-479a-516e-941b-0999caa064d9
DOI: 10.21203/rs.3.rs-2272009/v1

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