Compartment-Specific NK Cell Phenotypes Reveal Distinct Maturation and Activation States in Inflammatory Arthritis.

doi:10.1159/000548548

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Article

Compartment-Specific NK Cell Phenotypes Reveal Distinct Maturation and Activation States in Inflammatory Arthritis.

Journal of innate immunity - 1 Jan 2025

Deicher Franca Sophie, Exner Tarik, Claus Maren, Yousefian Schayan, Rodon Lea, Leonhardt Sophie Elisabeth, Distler Jörg H W, Watzl Carsten, Lorenz Hanns-Martin, Haas Simon, Hübschmann Daniel, Merkt Wolfgang

Abstract excerpt

<p>Introduction: Synovial natural killer (NK) cells contribute to inflammation in arthritis by secreting cytokines and modulating synovial fibroblast activation. The aim of this study was to describe systemic versus local inflammatory changes of NK cell subsets as well as their physical cell-cell interactions in arthritis patients. METHODS: Spectral flow cytometry was used to compare paired peripheral blood (PB)...

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Topics

Humans
Killer Cells, Natural
Female
Male
Middle Aged
Synovial Fluid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Lymphocyte Activation

Arthritis

Cell Communication

Aged

Phenotype

Inflammation

Cell Differentiation

Arthritis, Rheumatoid

Source

Open in PubMed Open full text

Identifiers

PMID: 41363790
DOI: 10.1159/000548548
PMCID: PMC12659454

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