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Article

Shared genetic architecture between Crohn's disease and IgA nephropathy: implications for a gut-immune-kidney axis.

Frontiers in immunology - 1 Jan 2026

Su Tao, Liang Mengjun, Gao Xiaohang, Lin Rui, Wu Hongzhen, Wu Luying, Zhang Min, Liu Tao, Peng Xiang, Zhao Junzhang, Deng Jun, Yao Jiayin, Zhi Min

Abstract excerpt

Background: Inflammatory bowel disease (IBD) and IgA nephropathy (IgAN) share features of mucosal immune dysregulation, but the genetic basis of their relationship and the contribution of specific IBD subtypes remain unclear. Methods: Using public genome-wide association study (GWAS) summary datasets, we performed bidirectional Mendelian randomization (MR) analyses in European and East Asian populations, together...

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Share to Crohn Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulonephritis, IGA

Share to Kidney

Share to Linkage Disequilibrium

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 42614547
DOI: 10.3389/fimmu.2026.1905767
PMCID: PMC13481795

Genes

CARD9
ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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