Article
Evaluation of the accuracy of imputed sequence variant genotypes and their utility for causal variant detection in cattle.
Genetics, selection, evolution : GSE - 21 Feb 2017
Pausch Hubert, MacLeod Iona M, Fries Ruedi, Emmerling Reiner, Bowman Phil J, Daetwyler Hans D, Goddard Michael E
Abstract excerpt
BACKGROUND: The availability of dense genotypes and whole-genome sequence variants from various sources offers the opportunity to compile large datasets consisting of tens of thousands of individuals with genotypes at millions of polymorphic sites that may enhance the power of genomic analyses. The imputation of missing genotypes ensures that all individuals have genotypes for a shared set of variants. RESULTS:...
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