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Article

Imputation of low-coverage sequencing data from 150,119 UK Biobank genomes.

Nature genetics - 1 Jul 2023

Rubinacci Simone, Hofmeister Robin J, Sousa da Mota Bárbara, Delaneau Olivier

Abstract excerpt

The release of 150,119 UK Biobank sequences represents an unprecedented opportunity as a reference panel to impute low-coverage whole-genome sequencing data with high accuracy but current methods cannot cope with the size of the data. Here we introduce GLIMPSE2, a low-coverage whole-genome sequencing imputation method that scales sublinearly in both the number of samples and markers, achieving efficient...

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Identifiers

PMID: 37386250
DOI: 10.1038/s41588-023-01438-3
PMCID: PMC10335927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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