Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity.

doi:10.1126/sciadv.aea6842

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Article

Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity.

Science advances - 8 May 2026

Lim Junghyun, Williams Katherine, Mittman Stephanie, Sanchez Patricia Pacheco, Rodriguez Ryan, Ogasawara Annie, Barnett Grace, Tleugabulova Mayra Cruz, Nabet Barzin Y, Hung Jeffrey, Marroquin Kevin A, Lau Shari, Lee Serena Y, Tyler Paul, Carbone Elizabeth T, Hough Bridget, Corpuz Janice, Murota Haruka, Dere Edward, Shiffman Smadar, Schutt Leah K, Gill Herman, Lau Julia, De Simone Marco, Tam Lucinda, Roose-Girma Merone, Warming Søren, Oh Soyoung A, Rutz Sascha, He Meng Xiao, Müller Sören, West Nathaniel R, Brewer Thomas F, Desai Prashant, Williams Simon, Ziai James, Qu Yan, Heger Klaus

Abstract excerpt

Checkpoint inhibitors targeting PD-1 and CTLA-4 have transformed cancer therapy. Both are genetically associated with autoimmune disorders. Moreover, certain immune-related adverse events and autoimmune risk variants are linked to the clinical efficacy of checkpoint inhibition. These associations suggest common principles governing successful cancer immunotherapy and autoimmune susceptibility. Here, we show that...

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Identifiers

PMID: 42090506
DOI: 10.1126/sciadv.aea6842
PMCID: PMC13148304

Genes

TREX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity.PMID 42090506Read ↗

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