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Article

Integrated DNA and RNA profiling refines prognostic stratification independent of therapeutic actionability in cholangiocarcinoma.

BMC cancer - 5 May 2026

Vendrell Julie A, Dalmon Inès, Cabello-Aguilar Simon, Colinge Jacques, Assenat Eric, Solassol Jérôme

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) exhibits marked biological heterogeneity. While genomic profiling identifies targetable alterations such as FGFR2 fusions and IDH1 mutations, transcriptomic analyses reveal distinct immune, proliferative and mesenchymal profiles. How these genomic and transcriptomic features jointly influence clinical outcomes remains unclear. METHODS: We performed integrated DNA and RNA...

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Source

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Identifiers

PMID: 42087104
DOI: 10.1186/s12885-026-16064-5
PMCID: PMC13312686

Genes

IDH1
KRAS
TP53
FGFR2
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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