Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets.

Journal of clinical pathology - 1 May 2016

Lee Hwajeong, Wang Kai, Johnson Adrienne, Jones David M, Ali Siraj M, Elvin Julia A, Yelensky Roman, Lipson Doron, Miller Vincent A, Stephens Philip J, Javle Milind, Ross Jeffrey S

Abstract excerpt

AIM: We queried whether extrahepatic cholangiocarcinoma featured clinically relevant genomic alterations that could lead to targeted therapy. METHODS: Comprehensive genomic profiling by hybridisation capture of up to 315 genes was performed on 99 clinically advanced extrahepatic cholangiocarcinoma. RESULTS: There were 60 male and 39 female patients with a median age of 60.5 years. A total of 400 alterations were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Bile Duct Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts, Intrahepatic

Share to Cholangiocarcinoma

Share to Gene Expression Profiling

Share to High-Throughput Nucleotide Sequencing

Share to Molecular Targeted Therapy

Share to Young Adult

Source

Identifiers

PMID: 26500333
DOI: 10.1136/jclinpath-2015-203394

Genes

ATM
BRAF
BRCA2
CCND1
CDK4
CDK6
ERBB2
FGFR1
FGFR2
FGFR3
GNAS
IDH1
KRAS
MDM2
NRAS
PTCH1
PTEN
RAF1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets.PMID 26500333Read ↗

Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for InterventionSemantic proximity Read ↗

New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation SequencingSemantic proximity Read ↗

Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles.Semantic proximity Read ↗

Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing.Semantic proximity Read ↗

Molecular Testing for Intrahepatic Cholangiocarcinoma: What, When, How?Semantic proximity Read ↗

Genomic Profiling of Biliary Tract Cancers and Implications for Clinical Practice.Semantic proximity Read ↗

Integrated DNA and RNA profiling refines prognostic stratification independent of therapeutic actionability in cholangiocarcinoma.Semantic proximity Read ↗

Biliary cancer: Utility of next-generation sequencing for clinical management.Semantic proximity Read ↗

Patient-led functional genomics identifies novel drivers of intrahepatic cholangiocarcinomaSemantic proximity Read ↗

Therapeutic yield of extensive molecular profiling in cholangiocarcinoma: a retrospective single center study.Semantic proximity Read ↗

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma.Semantic proximity Read ↗

Specific genomic alterations and prognostic analysis of perihilar cholangiocarcinoma and distal cholangiocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.