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Article

Molecular Testing for Intrahepatic Cholangiocarcinoma: What, When, How?

Journal of gastrointestinal cancer - 15 Jan 2026

Barsch Maryam, Dopfer Elaine-Pashupati, Schultheis Anne Maria, Quante Michael

Abstract excerpt

PURPOSE: Intrahepatic cholangiocarcinoma (iCCA) represents a biologically heterogeneous subgroup of biliary tract cancer (BTC) with a 5-year survival below 20%. Delayed diagnosis, intrinsic aggressiveness, and extensive intertumoral and intratumoral heterogeneity at the clinical, histopathological, and genomic level all contribute to this dismal outcome. Increasingly, treatment decisions in advanced iCCA depend...

Topics

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Bile Duct Neoplasms
Biomarkers, Tumor
Cholangiocarcinoma
High-Throughput Nucleotide Sequencing
Microsatellite Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Diagnostic Techniques

Molecular Targeted Therapy

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Identifiers

PMID: 41535645
DOI: 10.1007/s12029-026-01397-y
PMCID: PMC12804250

Genes

BTC
FGFR2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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