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Article

Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4.

Nature communications - 5 May 2026

Capponi Simona, Ehret Sandra, Camgöz Zeynep, Gather Fabian, Vaine Christine A, Özyerli-Göknar Ezgi, Follo Marie, Bragg D Cristopher, Vogel Tanja, Timmers H Th Marc

Abstract excerpt

Transcription and mRNA processing are tightly coupled regulatory layers on gene expression, and their perturbations underly human disorders. X-linked Dystonia-Parkinsonism (XDP) is a unique example of a human disease connecting aberrant mRNA processing and the basal transcription machinery. XDP is a rare, monogenic fatal neurodegenerative disorder, and a limited understanding of the underlying molecular...

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Source

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Identifiers

PMID: 42086561
DOI: 10.1038/s41467-026-72319-6
PMCID: PMC13144358

Genes

BRD4
TAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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