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Genetic Signatures of Positive Selection in Human Populations Adapted to High Altitude in Papua New Guinea

1 Aug 2024

Abstract excerpt

Papua New Guinea (PNG) hosts distinct environments mainly represented by the ecoregions of the Highlands and Lowlands that display increased altitude and a predominance of pathogens, respectively. Since its initial peopling approximately 50,000 years ago, inhabitants of these ecoregions might have differentially adapted to the environmental pressures exerted by each of them. However, the genetic basis of...

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PMID: 39173139
DOI: 10.1093/gbe/evae161

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