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Article

Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels.

Nature communications - 30 Apr 2024

André Mathilde, Brucato Nicolas, Hudjasov Georgi, Pankratov Vasili, Yermakovich Danat, Montinaro Francesco, Kreevan Rita, Kariwiga Jason, Muke John, Boland Anne, Deleuze Jean-François, Meyer Vincent, Evans Nicholas, Cox Murray P, Leavesley Matthew, Dannemann Michael, Org Tõnis, Metspalu Mait, Mondal Mayukh, Ricaut François-Xavier

Abstract excerpt

Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure, respectively. In this study, we explored the top genomics regions and the candidate driver SNPs for selection in these two populations using newly sequenced whole-genomes of 54 highlanders and 74 lowlanders. We identified two candidate SNPs under selection - one in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38688933
DOI: 10.1038/s41467-024-47735-1
PMCID: PMC11061283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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