Article
Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure.
Human genetics - 1 Sept 2013
Gomez Felicia, Tomas Gil, Ko Wen-Ya, Ranciaro Alessia, Froment Alain, Ibrahim Muntaser, Lema Godfrey, Nyambo Thomas B, Omar Sabah A, Wambebe Charles, Hirbo Jibril B, Rocha Jorge, Tishkoff Sarah A
Abstract excerpt
Malaria is one of the strongest selective pressures in recent human evolution. African populations have been and continue to be at risk for malarial infections. However, few studies have re-sequenced malaria susceptibility loci across geographically and genetically diverse groups in Africa. We examined nucleotide diversity at Intercellular adhesion molecule-1 (ICAM-1), a malaria susceptibility candidate locus, in...
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