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Article

Cu(I) and Cu(II) binding by hyperactive variants of the human CTR1 N-terminus: Insights from cellular and model peptide studies.

Journal of inorganic biochemistry - 1 Sept 2026

Ruth Kaylee, Post Emily, Wu Xiaobin, Kim Heejeong, Pushie M Jake, Escobedo Maria, Kuter Kristin, Lee Jaekwon, Haas Kathryn L

Abstract excerpt

Copper (Cu) trafficking requires precise control of Cu(II)/Cu(I) redox chemistry to enable cellular acquisition while preventing toxicity. Human Cu transporter 1 protein (hCTR1) mediates cellular Cu uptake, yet key molecular details governing its extracellular Cu acquisition remain unresolved. Although hCTR1 is a Cu(I)-selective pore, extracellular Cu may be presented by carriers in the Cu(II) oxidation state....

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Identifiers

PMID: 42085731
DOI: 10.1016/j.jinorgbio.2026.113339
PMCID: PMC13292886

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