Article
Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCTR1).
Metallomics : integrated biometal science - 1 Jul 2012
Du Xiubo, Wang Xinghao, Li Hongyan, Sun Hongzhe
Abstract excerpt
Copper transporter 1 (CTR1) is a transmembrane protein that imports copper(i) into yeast and mammalian cells. Surprisingly, the protein also mediates the uptake of platinum anticancer drugs, e.g. cisplatin and carboplatin. To study the effects of several metal-binding residues/motifs of hCTR1 on the transport of both Cu(+) and cisplatin, we have constructed Hela cells that stably express a series of hCTR1 variant...
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