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Article

Rate and regulation of copper transport by human copper transporter 1 (hCTR1).

The Journal of biological chemistry - 21 Jun 2013

Maryon Edward B, Molloy Shannon A, Ivy Kristin, Yu Huijun, Kaplan Jack H

Abstract excerpt

Human copper transporter 1 (hCTR1) is a homotrimer of a 190-amino acid monomer having three transmembrane domains believed to form a pore for copper permeation through the plasma membrane. The hCTR1-mediated copper transport mechanism is not well understood, nor has any measurement been made of the rate at which copper ions are transported by hCTR1. In this study, we estimated the rate of copper transport by the...

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Identifiers

PMID: 23658018
DOI: 10.1074/jbc.M112.442426
PMCID: PMC3689948

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