Article
Unresolved questions in human copper pump mechanisms.
Quarterly reviews of biophysics - 1 Nov 2015
Wittung-Stafshede Pernilla
Abstract excerpt
Copper (Cu) is an essential transition metal providing activity to key enzymes in the human body. To regulate the levels and avoid toxicity, cells have developed elaborate systems for loading these enzymes with Cu. Most Cu-dependent enzymes obtain the metal from the membrane-bound Cu pumps ATP7A/B in the Golgi network. ATP7A/B receives Cu from the cytoplasmic Cu chaperone Atox1 that acts as the cytoplasmic...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Biophysical Phenomena
- Catalysis
- Cation Transport Proteins
- Copper
- Copper-Transporting ATPases
- Cytoplasm
- DNA, Complementary
- Female
- Golgi Apparatus