Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.

doi:10.1016/j.celrep.2023.112212

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.

Cell reports - 28 Mar 2023

Ebisudani Toshiki, Hamamoto Junko, Togasaki Kazuhiro, Mitsuishi Akifumi, Sugihara Kai, Shinozaki Taro, Fukushima Takahiro, Kawasaki Kenta, Seino Takashi, Oda Mayumi, Hanyu Hikaru, Toshimitsu Kohta, Emoto Katsura, Hayashi Yuichiro, Asakura Keisuke, Johnson Todd A, Terai Hideki, Ikemura Shinnosuke, Kawada Ichiro, Ishii Makoto, Hishida Tomoyuki, Asamura Hisao, Soejima Kenzo, Nakagawa Hidewaki, Fujii Masayuki, Fukunaga Koichi, Yasuda Hiroyuki, Sato Toshiro

Abstract excerpt

Human lung cancer is a constellation of tumors with various histological and molecular properties. To build a preclinical platform that covers this broad disease spectrum, we obtained lung cancer specimens from multiple sources, including sputum and circulating tumor cells, and generated a living biobank consisting of 43 lines of patient-derived lung cancer organoids. The organoids recapitulated the histological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Specimen Banks

Share to Cancer-related gene regulation

Share to ErbB Receptors

Share to Genotype

Share to Lung Neoplasms

Share to Organoids

Share to Phenotype

Source

Open in PubMed

Identifiers

PMID: 36870059
DOI: 10.1016/j.celrep.2023.112212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.PMID 36870059Read ↗

Human Lung Adenocarcinoma-Derived Organoid Models for Drug ScreeningSemantic proximity Read ↗

Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinomaSemantic proximity Read ↗

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screeningSemantic proximity Read ↗

Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory diseaseSemantic proximity Read ↗

<em>Ex Vivo</em> Drug Testing of Patient-Derived Lung Organoids to Predict Treatment Responses for Personalized MedicineSemantic proximity Read ↗

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platformSemantic proximity Read ↗

Development of novel <i>in vitro</i> human alveolar epithelial cell models to study distal lung biology and diseaseSemantic proximity Read ↗

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platformSemantic proximity Read ↗

A robust human airway organoid platform enables scalable expansion and trajectory mapping of pulmonary neuroendocrine cellsSemantic proximity Read ↗

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA SequencingSemantic proximity Read ↗

Cellular Origins of EGFR‐Driven Lung Cancer Cells Determine Sensitivity to TherapySemantic proximity Read ↗

KrasG12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lungSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.