Article
Evolving concepts in lung carcinogenesis.
Seminars in respiratory and critical care medicine - 1 Feb 2011
Gomperts Brigitte N, Spira Avrum, Massion Pierre P, Walser Tonya C, Wistuba Ignacio I, Minna John D, Dubinett Steven M
Abstract excerpt
Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the "field of cancerization," and lung cancer stem cells in the initiation...
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