Article
Case report of a child with kidney disease: consideration of the risk of a single APOL1 G2 allele with a protective N264K variant on the G0 parental chromosome.
BMC nephrology - 4 May 2026
Greenberg Meidad, Tabachnikov Orly, Ben-Ruby Dror, Vivante Asaf, Skorecki Karl
Abstract excerpt
BACKGROUND: Apolipoprotein L1 (APOL1)-mediated kidney disease is causally associated with the G1/G2 risk alleles of the APOL1 gene, and shows incomplete penetrance shaped by environmental and genomic modifiers. A rare coding variant, N264K, observed on G0 or G2 variants, has been associated with protection in high-risk genotypes. Importantly, emerging data indicate that in some settings a single APOL1 risk allele...
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