Article

Strong protective effect of the<i>APOL1</i>p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

2023-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Black Americans have a significantly higher risk of developing chronic kidney disease (CKD), especially focal segmental glomerulosclerosis (FSGS), than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play a major role in this disparity. While 13% of Black Americans carry the high-risk recessive genotypes, only a fraction of these individuals develops FSGS or kidney failure,...

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Literature Corpus work: 291885ab-7089-597a-be84-3c9792faebdd
DOI: 10.1101/2023.08.02.23293554

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