The APOL1 p.N264K variant is co-inherited with the G2 kidney disease risk variant through a proximity recombination event.

doi:10.1093/g3journal/jkae290

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The APOL1 p.N264K variant is co-inherited with the G2 kidney disease risk variant through a proximity recombination event.

G3 (Bethesda, Md.) - 5 Feb 2025

Simeone Christopher A, McNulty Michelle T, Gupta Yask, Genovese Giulio, Sampson Matthew G, Sanna-Cherchi Simone, Friedman David J, Pollak Martin R

Abstract excerpt

Black Americans are 3-4 times more likely to develop nondiabetic kidney disease than other populations. Exclusively found in people of recent African (AFR) ancestry, risk variants in Apolipoprotein L1 (APOL1) termed G1 and G2 contribute significantly to this increased susceptibility. Our group and others showed that a missense variant in APOL1, rs73885316 (p.N264K, "M1"), is remarkably protective against APOL1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein L1

Share to Black or African American

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Kidney Diseases

Share to Polymorphism, Single Nucleotide

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 39658338
DOI: 10.1093/g3journal/jkae290
PMCID: PMC11797048

Genes

APOL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The APOL1 p.N264K variant is co-inherited with the G2 kidney disease risk variant through a proximity recombination event.PMID 39658338Read ↗

APOL1 Nephropathy: A Population Genetics and Evolutionary Medicine Detective Story.Semantic proximity Read ↗

APOL1 and APOL1-Associated Kidney Disease: A Common Disease, an Unusual Disease Gene – Proceedings of the Henry Shavelle ProfessorshipSemantic proximity Read ↗

APOL1 kidney risk alleles: population genetics and disease associations.Semantic proximity Read ↗

Population genetics of chronic kidney disease: the evolving story of APOL1.Semantic proximity Read ↗

Phenome-wide analysis reveals epistatic associations between APOL1 variants and chronic kidney disease and multiple other disorders.Semantic proximity Read ↗

Case report of a child with kidney disease: consideration of the risk of a single APOL1 G2 allele with a protective N264K variant on the G0 parental chromosome.Semantic proximity Read ↗

Gene of the month: APOL1.Semantic proximity Read ↗

The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.Semantic proximity Read ↗

Strong protective effect of the<i>APOL1</i>p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney diseaseSemantic proximity Read ↗

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.Semantic proximity Read ↗

APOL1 and Kidney Disease: From Genetics to Biology.Semantic proximity Read ↗

APOL1 variants G1, G2 and N264K affect APOL1 plasma protein concentration: a UK Biobank studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.