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Article

Multi-Omics Mendelian Randomization and Clinical Validation Implicate NLRP6 as a Candidate Autophagy-Related Gene in Systemic Lupus Erythematosus.

Genes - 16 Apr 2026

Nie Daan, Yin Jianguo, Tu Wei, Huang Kecheng, Wan Jing, Yu Yikai, Wang Bei, Chen Yu, Lin Shengyan, Zeng Zhipeng

Abstract excerpt

Background/Objectives: Autophagy plays a role in systemic lupus erythematosus (SLE) pathogenesis. Nevertheless, the specific genetic determinants underpinning this process remain poorly characterized. Summary data-based Mendelian randomization (SMR) analysis was therefore utilized to pinpoint autophagy-related genes associated with SLE risk. Methods: We analyzed 700 autophagy-related genes, integrating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42074584
DOI: 10.3390/genes17040466
PMCID: PMC13115566

Genes

NLRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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