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Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis

5 Mar 2025

Abstract excerpt

BACKGROUND: Autophagy is associated with the development of rheumatoid arthritis (RA), but its genetic pathological mechanisms remain incompletely understood. In this study, we employed summary-data-based Mendelian randomization (SMR) and co-localization analysis to systematically investigate the relationship between autophagy-related genes and RA. METHODS: We obtained summary data on blood methylation (mQTL),...

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Share to Autophagy in Disease and Therapy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40045304
DOI: 10.1186/s12967-025-06288-7

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