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Article

Autophagic molecular network in IS pathogenesis: A multi-omics Mendelian randomization study.

Medicine - 23 Jan 2026

Nie Hao, Zhang Li, Hei Yunpeng, Ma Tao, Xu Xin, Zhang Maoxian

Abstract excerpt

This study aimed to identify autophagy-related genes with a causal role in ischemic stroke (IS) risk using a multi-omics Mendelian randomization (MR) approach. We integrated summary-level data for blood-derived DNA methylation (mQTLs), expression (eQTLs), and protein (pQTLs) quantitative trait loci for 594 autophagy-related genes with large-scale IS genome-wide association studies for discovery (GCST006908) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41578456
DOI: 10.1097/MD.0000000000047249
PMCID: PMC12851650

Genes

DYNLT1
CDKN1A
LEP
PARK7
RRAGD
SLC35D3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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