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Article

Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Aug 2013

Copley Catherine O, Duncan Jeremy S, Liu Chang, Cheng Haixia, Deans Michael R

Abstract excerpt

The distinctive planar polarity of auditory hair cells is evident in the polarized organization of the stereociliary bundle. Mutations in the core planar cell polarity gene Van Gogh-like 2 (Vangl2) result in hair cells that fail to properly orient their stereociliary bundles along the mediolateral axis of the cochlea. The severity of this phenotype is graded along the length of the cochlea, similar to the hair...

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Identifiers

PMID: 23986237
DOI: 10.1523/JNEUROSCI.1307-13.2013
PMCID: PMC3756750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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