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Article

Reciprocal interaction between depression and pain: results from a comprehensive bidirectional Mendelian randomization study and functional annotation analysis.

Pain - 1 Jan 2022

Tang Bowen, Meng Weihua, Hägg Sara, Burgess Stephen, Jiang Xia

Abstract excerpt

ABSTRACT: To understand a putative causal link for depression and pain, we retrieved summary statistics from genome-wide association studies conducted for pain at 7 different body sites (N = 151,922-226,683) and major depression disorder (MDD, Ncase/control = 246,363/561,190). We conducted a bidirectional Mendelian randomization analysis using distinct genome-wide association studies-identified single nucleotide...

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Identifiers

PMID: 34924553
DOI: 10.1097/j.pain.0000000000002305
PMCID: PMC8675051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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