Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic and structural analysis of the endocannabinoid system in Moroccans: A novel CNR1 variant (V392A) impairs CB1 receptor stability.

PloS one - 1 Jan 2026

Abbou Hanane, Festali Rihab, Chemao-Elfihri Mohammed Walid, Hakmi Mohammed, Kartti Souad, Boutayeb Saber, Belyamani Lahcen, Eljaoudi Rachid

Abstract excerpt

The Endocannabinoid System (ECS) is vital for human physiology, and genetic variation within its components can alter function and therapeutic responses. The genetically diverse Moroccan population offers a unique opportunity for pharmacogenomic insight. This study performs a comprehensive genomic analysis of 11 core ECS genes in 109 Moroccan individuals, identifying 170 novel variants. We then performed a deep...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocannabinoids
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Molecular Dynamics Simulation

Share to Morocco

Share to Mutation

Share to Protein Stability

Share to Receptor, Cannabinoid, CB1

Source

Open in PubMed Open full text

Identifiers

PMID: 42060668
DOI: 10.1371/journal.pone.0347606
PMCID: PMC13132444

Genes

CNR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic and structural analysis of the endocannabinoid system in Moroccans: A novel CNR1 variant (V392A) impairs CB1 receptor stability.PMID 42060668Read ↗

Cannabinoid CB2 Receptor Functional Variation (Q63R) is Associated with COVID-19 Severity: from Human Study to Molecular DockingSemantic proximity Read ↗

Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations.Semantic proximity Read ↗

Exploiting in silico structural analysis to introduce emerging genotype–phenotype correlations in DHCR24-related sterol biosynthesis disorder: a case studySemantic proximity Read ↗

Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking.Semantic proximity Read ↗

In silico characterization of MC4R variants reveals insights into Setmelanotide pharmacogenomics and personalized medicine for obesity.Semantic proximity Read ↗

Characterizing clinically relevant natural variants of GPCRs using computational approaches.Semantic proximity Read ↗

Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans.Semantic proximity Read ↗

A Novel <scp> <i>NR3C1</i> </scp> Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural ModelingSemantic proximity Read ↗

Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis StudySemantic proximity Read ↗

Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translationSemantic proximity Read ↗

Role of the endocannabinoid system in fragile X syndrome: potential mechanisms for benefit from cannabidiol treatmentSemantic proximity Read ↗

A cannabidiol-sensitive region involved in the allosteric modulation of the α7 nicotinic receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.