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Article

In silico characterization of MC4R variants reveals insights into Setmelanotide pharmacogenomics and personalized medicine for obesity.

Personalized medicine - 1 Jun 2026

Nunes Bruno Fonseca, de Souza Grinevicius Valdelúcia Maria Alves, Pedroza Rozangela Curi, Filippin-Monteiro Fabíola Branco

Abstract excerpt

AIMS: The Melanocortin-4 receptor is a key regulator of energy homeostasis, and loss-of-function variants are the most common cause of monogenic obesity. This study aimed to characterize MC4R genetic variants and evaluate their potential impact on receptor function and interaction with Setmelanotide. MATERIALS AND METHODS: An in silico approach was applied to analyze MC4R single nucleotide polymorphisms (SNPs)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

Source

Identifiers

PMID: 42205046
DOI: 10.1080/17410541.2026.2679124

Genes

MC4R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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