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Article

Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking.

Archives of virology - 1 Nov 2021

Rastegar Mostafa, Samadizadeh Saeed, Yasaghi Mohammad, Moradi Abdolvahab, Tabarraei Alijan, Salimi Vahid, Tahamtan Alireza

Abstract excerpt

Evidence supports a role of host genetic diversity in the clinical course of coronavirus disease 2019 (COVID-19). Variation in the cannabinoid CB2 receptor gene (CNR2) could affect the regulatory action of endocannabinoids on the immune system, resulting in an increased risk of various inflammatory diseases. The present study investigated the relationship between the CNR2-Q63R variant and COVID-19 severity. A...

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Identifiers

PMID: 34514519
DOI: 10.1007/s00705-021-05223-7
PMCID: PMC8435402

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