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Article

A cannabidiol-sensitive region involved in the allosteric modulation of the α7 nicotinic receptor.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2026

Chrestia Juan Facundo, Viscarra Franco, Biggin Philip C, Bermudez Isabel, Bouzat Cecilia

Abstract excerpt

Cannabidiol (CBD), a nonpsychoactive phytocannabinoid from Cannabis sativa, modulates the α7 nicotinic acetylcholine receptor (α7 nAChR), a key target in neurological, neurodegenerative, and inflammatory disorders. However, the molecular basis of this modulation remains unresolved. By combining single-channel recordings, molecular dynamics (MD) simulations, and targeted mutagenesis, we identify an allosteric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42296345
DOI: 10.1073/pnas.2535398123
PMCID: PMC13291680

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