The impact for causal associations between common diseases and inflammatory bowel disease: a disease-wide bidirectional Mendelian randomization study.

doi:10.1007/s00011-026-02304-8

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Article

The impact for causal associations between common diseases and inflammatory bowel disease: a disease-wide bidirectional Mendelian randomization study.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 5 Sept 2026

Sun Yuxuan, Liang Zixin, Ou Zehua, Gao Lei, Wang Yong-Fei, Yuan Jinqiu, Yu Guangjun, Sun Rui

Abstract excerpt

OBJECTIVES: Observational studies on associations between various diseases and inflammatory bowel disease (IBD) are often limited by confounding and reverse causation. We aimed to assess potential causal relationships between a wide range of diseases and IBD, including Crohn's disease (CD) and ulcerative colitis (UC). METHODS: We performed a comprehensive bidirectional Mendelian randomization (MR) analysis of 104...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Genome-Wide Association Study
Inflammatory Bowel Diseases
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Quantitative Trait Loci

Crohn Disease

Asthma

Polymorphism, Single Nucleotide

Colitis, Ulcerative

CARD Signaling Adaptor Proteins

Multiple Sclerosis

Source

Open in PubMed Open full text

Identifiers

PMID: 42700258
DOI: 10.1007/s00011-026-02304-8
PMCID: PMC13546168

Genes

CARD9
RGS14

Provenance

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