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Article

Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.

Journal of cellular and molecular medicine - 1 Jul 2026

Yang Juan, Zhang Lida, Wang Xiaqing, Yang Yuxiu

Abstract excerpt

Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract, where oxidative stress is a significant contributing factor to its pathogenesis. This study utilized multi-omics data, including RNA sequencing from the GSE216447 dataset and three genome-wide association studies (GWAS) datasets (ieu-a-10, ieu-a-11, ieu-a-13), to investigate the molecular networks related to oxidative stress...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42458727
DOI: 10.1111/jcmm.71257
PMCID: PMC13373136

Genes

CD101
HMGCR
ASCC3
ELOVL6
FASN
OSGIN1
PHLDA2
PHLDA3
SCPEP1
ABCB9
ACTA2
ARL4C
IL24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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