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Article

HDAC Inhibition Induces Transient Phenotypic Inertia in Dormant OCCC Spheroids by Derepression of Cell Cycle Genes.

Cells - 10 Apr 2026

Cheng Sylvia, Kolendowski Bart, Ramos-Valdes Yudith, Shepherd Trevor G, DiMattia Gabriel E

Abstract excerpt

Multicellular cancer cell aggregates, termed spheroids, are anoikis-resistant, avascular, heterogeneous structures responsible for transcoelomic metastasis of ovarian clear cell carcinoma (OCCC). OCCC is a rare subtype of ovarian cancer with high ARID1A gene mutation rates, resulting in genome-wide changes to H3K27Ac levels and histone deacetylase (HDAC) function. Our study investigated the utility of HDAC...

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Identifiers

PMID: 42041541
DOI: 10.3390/cells15080673
PMCID: PMC13114744

Genes

ARID1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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