Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.

doi:10.1371/journal.ppat.1009402

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Article

Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.

PLoS pathogens - 1 Mar 2021

Walker Forrest C, Hassan Ebrahim, Peterson Stefan T, Rodgers Rachel, Schriefer Lawrence A, Thompson Cassandra E, Li Yuhao, Kalugotla Gowri, Blum-Johnston Carla, Lawrence Dylan, McCune Broc T, Graziano Vincent R, Lushniak Larissa, Lee Sanghyun, Roth Alexa N, Karst Stephanie M, Nice Timothy J, Miner Jonathan J, Wilen Craig B, Baldridge Megan T

Abstract excerpt

Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary potential of this enteric virus. In animals lacking type I IFN signaling, the nonlethal MNoV strain CR6 rapidly acquired enhanced virulence via conversion of a single...

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PMID: 33705489
DOI: 10.1371/journal.ppat.1009402
PMCID: PMC7987144

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