Animal and human RNA viruses: genetic variability and ability to overcome vaccines.

Abstract excerpt

RNA viruses, in general, exhibit high mutation rates; this is mainly due to the low fidelity displayed by the RNA-dependent polymerases required for their replication that lack the proofreading machinery to correct misincorporated nucleotides and produce high mutation rates. This lack of replication fidelity, together with the fact that RNA viruses can undergo spontaneous mutations, results in genetic variants...

Topics

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• Animal Virus Infections Studies
• DNA-Directed RNA Polymerases
• Genetic Variation
• Mutation
• RNA Viruses