Article
Differential impact of Tafenoquine and Primaquine on Plasmodium vivax recurrence: the role of CYP2D6 variants.
Antimicrobial agents and chemotherapy - 3 Jun 2026
Godinho Vanessa Karina Castro, Mwangi Victor Irungu, Morais Manuela Crispim, Lopes Adriana Patricia Brelaz, Alves Jessica Rafaela Dos Santos, Brito Marcelo Augusto Mota, Lacerda Marcus Vinicius Guimarães de, Trindade Maranhão Costa Fabio, Almeida Anne Cristine Gomes de, Melo Gisely Cardoso de
Abstract excerpt
Malaria, particularly by Plasmodium vivax, remains a significant public health challenge in endemic regions. P. vivax has the dormant liver-stage hypnozoites that can reactivate, causing relapses, even after the initial blood-stage infection has been cleared. The prevention of these relapses hinges on the use of 8-aminoquinolines such as primaquine (PQ) and tafenoquine (TQ). However, the efficacy of these...
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