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Efficacy of Primaquine for the Radical Cure of Plasmodium vivax Malaria in Northeast Myanmar and the Impact of Cytochrome P450 2D6 Genotypes.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 16 Sept 2025

Zeng Weilin, Liu Huaie, Malla Pallavi, Zhao Yan, Menezes Lynette, Cao Yaming, Wang Chengqi, Yang Zhaoqing, Cui Liwang

Abstract excerpt

BACKGROUND: The antirelapse activity of primaquine (PQ) for Plasmodium vivax malaria depends on the host cytochrome P450 2D6 (CYP2D6) enzyme activity. This study aimed to assess the efficacy of PQ for the radical cure of P. vivax malaria in the Greater Mekong Subregion and determine the association of the post-PQ recurrences with CYP2D6 genotypes. METHODS: In 2014-2017, a total of 239 patients with uncomplicated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40152264
DOI: 10.1093/cid/ciae482
PMCID: PMC12448580

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